Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy

In this study, adaptation of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional glomerular damage, results in a re-sialylation event associated with sequentially increased levels of glomerular linkage-specific sialyltransferase transcript levels and activity. The results of these experiments provide insight into specific molecular responses of podocytes to injury, in addition to demonstrating the versatility of this animal model for descriptive and mechanistic studies regarding podocyte sialobiology.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Pathobiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Ringenberg, Michael Alan

Contributors dc:contributor

• Vimr, Eric R.

• Biology, Animal Physiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3044208

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/87620