Expression of Cytosolic and Mitochondrial Superoxide Dismutases: Their Role in the Chemoresistance of Malignant Melanoma

In summary, MM cells that are exposed to sublethal doses of ROS generating chemotherapeutic agents are able to modulate antioxidant defenses as an adaptive response. By upregulating Mn-SOD without commensurate increase in catalase activities, an imbalance in oxidant processing occurs. This imbalance in the antioxidant defense system results in accumulation of peroxides, which can act as secondary messengers to enhance cell survival pathways.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Clinical Medicine

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Sulaimon, Shola Shakirat

Contributors dc:contributor

• Barbara E. Kitchell

• Biology, Cell

Language dc:language

eng

Identifier

(MiAaPQ)AAI3086192

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/87124