Characterization and Efficacy of Cobalt Compounds as in Vivo Magnetic Resonance Temperature Probes

This work demonstrates that $\sp{59}$Co NMR can be used to determine temperature changes in vivo. The liposome encapsulated $\rm \lbrack Co(en)\sb3\rbrack Cl\sb3$ and Co(Hp) (Im) $\sb2\sp+$ show promise as in vivo MR temperature probes. The relatively high accumulation of Co(Hp) (Im) $\sb2\sp+$ in tumors indicates that this configuration may have potential for measuring tumor temperature during hyperthermic treatment of cancer.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Wilmes, Lisa Jeanne

Contributors dc:contributor

• Richard L. Magin

• Biophysics, General

Language dc:language

eng

Identifier

(MiAaPQ)AAI9904623

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/85485