Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach

Cancer and infectious diseases represent huge health threats to societies around the globe. Bisphosphonate drugs, long known for their ability to treat bone resorption diseases, have also served as the template for designing new agents against a variety of other diseases. In this work, computational modeling methods have been applied to design the newest series of bisphosphonate molecules optimized for additional targets relating to parasitic diseases, bacterial cell wall biosynthesis, and cancer. These modeling efforts have not only resulted in more potent inhibitors, but have also increased our understanding of these disease targets, which include T. cruzi hexokinase, farnesyl diphosphate synthase, undecaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics and Computational Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Hudock, Michael

Contributors dc:contributor

• Oldfield, Eric

• Chemistry, Pharmaceutical

Language dc:language

eng

Identifier

(MiAaPQ)AAI3314794

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/85467