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University of Illinois at Urbana-Champaign
Coregulatory Transcription Factors and Spermatogenesis
Abstract
dc:descriptionThe BTB was hypothesized to be deficient in Etv5 -/- mice, and that this was mediated by Claudin 5 (CLD5). In both Etv5-/- and W/Wnu mice, the BTB was leaky. Examination of CLD5 expression among mice of various ages and phenotypes revealed the following: both ETV5 and germ cells were necessary for seminiferous epithelial CLD5 expression; CLD5 expression was ETV5 independent in vascular endothelium; and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli cell CLD5 has a role in BTB function, but also a non-tight junction role in spermatogonia.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Biology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Morrow, Carla K.
- Contributors dc:contributor
-
- Hess, Rex A.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3337879
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/85379