Back to results
University of Illinois at Urbana-Champaign
Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
Abstract
dc:descriptionResults of the bioequivalence analysis indicated the model was not equivalent. The model was examined using time averaged inputs of tissue blood flows and using stepped changes in tissue blood flow representing measured changes in individual experimental subjects. Analysis of partial areas under the curve suggested the model was better at predicting the elimination than the distribution of fentanyl, although the partial areas under the curve were still not equivalent.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Biology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Grimm, Kurt Allan
- Contributors dc:contributor
-
- David R. Gross
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3070001
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/85344