The Role of T Cell Receptor: Peptide MHC Affinity in T Cell Activation

Engineering of TCRs requires stabilization of the receptor prior to engineering for higher affinity. Chapter 4 details the engineering of a high affinity TCR in its native state, without the need for stabilization, using a T cell display system. T cells bearing the newly isolated TCR bound pepMHC and were activated in the absence of co-receptor. This result demonstrates the feasibility of engineering full-length TCRs on the surface of T cells using a retroviral vector.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Chervin, Adam S.

Contributors dc:contributor

• Kranz, David M.

• Chemistry, Biochemistry

Language dc:language

eng

Identifier

(MiAaPQ)AAI3362752

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84862