Engineering and Characterization of High-Affinity T Cell Receptors

In Chapter 6, the role of TCR affinity in T cell activation was studied using CD8-negative T cells, as well as T cells expressing the co-receptor CD8. The peptide sensitivity of T cells that expressed the highest-affinity TCRs reached a plateau, suggesting the existence of an affinity maximum for T cell activation. Furthermore, CD8 requirements were directly related to the affinity of the TCR.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Holler, Phillip David

Contributors dc:contributor

• Kranz, David M.

• Health Sciences, Immunology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3070327

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84786