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University of Illinois at Urbana-Champaign
Studies on the Stereochemistry and Mechanism of Taxadiene Biosynthesis
Abstract
dc:descriptionEnzyme-mediated cyclization of GPP, FPP, and GGPP goes through various carbocationic intermediates, and methoxy analogs of these substrates would provide strong stabilization towards the carbocation intermediates. Upon release from the enzyme, the non-natural products would provide valuable insights to the enzyme mechanisms that would otherwise be unavailable. Methoxy-substituted nor analogs of geraniol, farnesol, and geranylgeraniol were prepared by alkylation of carbanions generated from allylic ethers.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Jin, Qingwu
- Contributors dc:contributor
-
- Coates, Robert M.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI9944896
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84445