Design, Syntheses and Functional Studies of DNA Binding Metal Complexes

Both cis- and trans- (Pt(NH$\sb3)\sb2$(4-Me-Py)Cl$\rbrack\sp+$ bind DNA covalently at the N7-site of the guanines forming a monodentate adduct, but only the cis-isomer has anticancer activity. The interactions of these platinum complexes with the DNA-heptamer d(CCTGTCC):d(GGACAGG) were examined and a NMR based high resolution structure was determined. Surprisingly both platinum-DNA complexes do not form a very stable complex with its complementary strand. Over time the platinum-DNA complex decomposes and either the 2-methyl-pyridinium group or the platinum complex itself is detached. No interstrand crosslinking was observed.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Bauer, Cornelia

Contributors dc:contributor

• Wang, Andrew H.J.

• Chemistry, Pharmaceutical

Language dc:language

eng

Identifier

(MiAaPQ)AAI9904391

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84406