University of Illinois at Urbana-Champaign
Interactions of Anticancer Drugs With DNA Studied by High-Resolution NMR Spectroscopy
Abstract
dc:descriptionThe anthracycline daunorubicin has been widely used to treat acute leukemia clinically. The newly designed bisanthracycline bisintercalator WP631 has shown promising results against the anthracycline resistance that is due to the transport proteins, e.g., P-glycoprotein. The 3D structures of 1:1 WP631/d(CGTACG)$\sb2$ and 1:1 WP631/d(CGJACG)$\sb2$ showed that the aglycone rings intercalate slightly shallower than those in the 2:1 DAU/d(CGTACG)$\sb2$ and the daunosamine moieties are elevated from the minor groove floor, which would explain why the binding constant of WP631 to DNA is 3 orders less than expected. WP631 has also shown tight binding to modified DNA d(CGJACG)$\sb2.$ The 3D structures of these two complexes have pointed the direction for the future design of bisanthracycline drugs.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Lian, Chenyang
- Contributors dc:contributor
-
- Wang, Andrew H.J.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI9737178
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84367