Synthesis and Study of Biomimetic Ion Channels: (1) Toward the Development of a Cyclic Peptide-Based Redox-Gated Channel, and (2) Investigations Into the Effect of Pore Size on the Ion Selectivity of an Aminocyclodextrin Channel

To probe the correlation between pore size and ion selectivity, a channel with an alpha-cyclodextrin macrocycle was synthesized and its transport properties were compared with those of an analogous channel with a larger beta-cyclodextrin pore. The anion transport profile of the alpha-cyclodextrin channel (ClO 4- > I- > Br- > NO3- > Cl-) differed from that of its beta-cyclodextrin counterpart (ClO4 - > I- > NO3- > Br- > Cl-) in the order of bromide and nitrate transport rates. While quantitative comparisons could not be made between the rates of ion transport through the alpha- and beta-cyclodextrin channels, a number of qualitative differences were observed between the two sets of transport data. Namely, the smaller pore of the alpha-cyclodextrin channel appeared to bind Cl- in such a way as to restrict Na+ transport. In addition, the larger I- and ClO4- ions seemed to pass through channel-induced membrane defects rather than through the smaller pore of the alpha-cyclodextrin channel.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Schmidt, Emily Grace

Contributors dc:contributor

• Mary S. Gin

• Chemistry, Organic

Language dc:language

eng

Identifier

(MiAaPQ)AAI3270020

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84264