Design and Synthesis of Small Molecule Regulators of Steroid Receptor Action

Another way of blocking estrogen-related actions is to prevent transcription via the creation of coactivator binding inhibitors. The estrogen receptor contains a region in the ligand binding domain where coactivator proteins for transcription are able to dock. Using a small molecule specifically designed to bind to this region with a high affinity effectively inhibits transcription. Molecules were designed and synthesized to mimic the interactions between the coactivator protein and the estrogen receptor.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Trogden, Bridget G.

Contributors dc:contributor

• Katzenellenbogen, John A.

• Chemistry, Organic

Language dc:language

eng

Identifier

(MiAaPQ)AAI3199157

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84203