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University of Illinois at Urbana-Champaign
Part I. A Novel Vitamin B(12) Catalyzed Carbon-Carbon Bond Forming Reaction: Mechanistic Investigations and Aryl Alkene Cyclization. Part II. Mechanistic Investigation of Prostaglandin H Synthase Through the Synthesis of Site Specifically Substituted Arachidonic Acids
Abstract
dc:descriptionFinally, the syntheses of site-specifically deuterated arachidonic acids containing a remote tritium label are reported. These radiolabeled substrates would allow the characterization of the initial radical intermediate for PGHS under aerobic conditions and enzyme turnover. The substrates could also be used to investigate other oxygenase enzymes, such as lipoxygenases and aspirin-treated PGHS.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- McGinley, Christopher
- Contributors dc:contributor
-
- van der Donk, Wilfred A.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3199081
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84194