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University of Illinois at Urbana-Champaign
Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
Abstract
dc:descriptionBy attaching the fluorophore directly onto the ligand-binding domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and function that nicely complement x-ray crystallography and NMR spectroscopy.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Tamrazi, Anobel
- Contributors dc:contributor
-
- Katzenellenbogen, John A.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3086195
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84109