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University of Illinois at Urbana-Champaign
An Approach to the Total Synthesis of the Protein Phosphatase 1 and 2A Inhibitor Microcystin -Lr
Abstract
dc:descriptionThe present study is an investigation of different synthetic routes to the natural product utilizing several protecting group strategies. Extensive studies were required to gain insight into the susceptibility of the intermediates to reaction conditions. This work has led to the first synthetic route to the intermediate microcystin-LR-di-Boc-guanidine which can be converted to a constitutional isomer of microcystin-LR. Mass spectral analysis and HPLC retention time show the presence of microcystin-LR although a clean 1H NMR could not be obtained.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Costerison, Jennifer Riggs
- Contributors dc:contributor
-
- Rinehart, Kenneth L., Jr.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3070284
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84076