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University of Illinois at Urbana-Champaign
Mechanistic Investigations and Synthetic Development of (-)-Sparteine Mediated Asymmetric Benzylic Lithiation-Substitution Reactions of Secondary Amides
Abstract
dc:descriptionThe synthetic utility of the lithiation-substitutions of N-(2-phenethyl)isobutyramide has also been investigated. Enantioenriched substituted products have been carried forward in the synthesis of 1,4-disubstituted dihydro- and tetrahydroisoquinolines. Variation of either substituent is convenient as the 4-position substituent is determined by choice of the electrophile in the lithiation-substitution and the 1-position substituent is introduced prior to cyclization.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Laumer, Jason Matthew
- Contributors dc:contributor
-
- Beak, Peter
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3030451
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84057