Defining Mechanisms Contributing to Porcine MHC Class II Diversity

Comparisons of He in domestic and Wild populations revealed significant differences within Europe (P=0.031) at the DRB1 loci, but not the DQB loci (P=0.503). Within Asia, significant differences were observed (DQB: P=0.011 and DRB1: P=0.015) at both MHC loci, between the domestic and Wild boar populations. The European and Asian domestic populations exhibited a higher level of DQB amino acid diversity (0.093 and 0.093, respectively) when compared to the respective Wild boar populations (0.047 and 0.055). Conversely, analyses of DRB1 amino acid diversity revealed lower levels for both European and Asian domestic populations (0.125 and 0.121, respectively) when compared to European and Asian Wild boar populations (0.170 and 0.152, respectively). Lower DQB diversity in the Wild boar populations when compared to the domestic populations may suggest relaxed selection in the domestic populations at the DQB locus. Taken together, these data suggest that MHC polymorphisms have been selectively maintained, possibly by balancing selection, having overcome the effects of nonselective factors, artificial selection, distinct ancestral origins therefore lacking the presence of geographic signatures.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Luetkemeier, Erin Suzanne

Contributors dc:contributor

• Schook, Lawrence B.

• Biology, Genetics

Language dc:language

eng

Identifier

(MiAaPQ)AAI3347440

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/83618