Functional Peptidomics: Combining Discovery-Based Mass Spectrometry and Neurophysiology to Explore Communication of Phase -Resetting Cues in the Rat Suprachiasmatic Nucleus

This thesis justifies functional peptidomics as a useful approach to understanding intercellular signaling mechanisms regulating SCN clock phase. Directly detecting dynamic release properties of peptides from the SCN brain slice provides new insights on a complex phenomenon phenomenon. The identification and characterization of little SAAS serves as an example of the facets of SCN physiology left to be discovered. Utilization of peptidomics strategies will significantly advance understanding of timing homeostatic mechanisms.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Neuroscience

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Atkins, Norman, Jr

Contributors dc:contributor

• Martha L. Gillette

• Biology, Physiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3391876

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82529