Cognitive Effects of Estrogens During Aging

To investigate possible neurochemical mechanisms, densities of D1 and D2 dopamine receptors and dopamine transporter (DAT) were measured in the prefrontal cortex of genistein-treated rats by Western blot. D1 and D2 densities did not differ between groups. However, DAT density was lower in the control group relative to the genistein groups. DAT was also lower in old rats. These results suggest that different aspects of executive function are differentially sensitive to estrogen or genistein as well as aging, and that altered prefrontal dopamine could play an important role in mediating the effects of estrogens on executive function.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Neuroscience

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Wang, Victor C.

Contributors dc:contributor

• Schantz, Susan L.

• Biology, Neuroscience

Language dc:language

eng

Identifier

(MiAaPQ)AAI3337960

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82521