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University of Illinois at Urbana-Champaign
Phase Inversion Dynamics of Polylactic Glycolic Acid Solutions Related to Biopharmaceutical Drug Delivery
Abstract
dc:descriptionProtein burst on injection was entirely eliminated when the protein particle was densified with stearic acid and placed in a slow phase-inverting depot formulation. Particle densification can potentially be used with any protein or highly soluble drug agent, unlike other techniques that are protein specific. Taking advantage of the effects of low aqueous affinity and densification, a PLGA solution depot was produced that sustained serum hGH levels in normal rats at 10 to 200 ng/mL for 28 days.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemical Engineering
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Brodbeck, Kevin J.
- Contributors dc:contributor
-
- McHugh, Anthony J.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI9952973
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/82471