Microfluidic Platforms for Investigating Cell Migration

Furthermore, these studies quantified the relative effects of E-cadherin expression and adhesive ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic mammary epithelial tumor cells MDA-MB-231. These investigations show that increased E-cadherin expression reduces cell motility by both adhesion-dependent and adhesion-independent mechanisms. By controlling both the substratum composition and E-cadherin expression we defined conditions that favor either the adhesion-independent or the adhesion-dependent mechanism of motility suppression.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Silvestre, Jonathan

Contributors dc:contributor

• Leckband, Deborah E.
• Kenis, Paul J.A.

• Engineering, Chemical

Language dc:language

eng

Identifier

(MiAaPQ)AAI3337924

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82414