Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins

Finally, fluorescence imaging assessed cadherin clustering and actin organization in E-cadherin expressing cells cultured on E-, N-, and C-cadherin ectodomains. As expected, the formation of filamentous actin correlated with the Rac activation amplitudes in E-cadherin expressing cells. The results also showed that lateral cadherin clustering, which is thought to be an initial response to cadherin ligation, occurs in E-cadherin expressing cells as a result of both heterophilic and homophilic binding. However, I also showed that lateral cadherin clustering is not a cadherin-specific response. These results are important because they suggest that cadherin-dependent differences in intracellular signaling may play a greater role in cell sorting than the biophysical properties of bonds between ectodomain subtypes.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Lee, Keng Jin

Contributors dc:contributor

• Leckband, Deborah E.

• Engineering, Chemical

Language dc:language

eng

Identifier

(MiAaPQ)AAI3337841

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82413