Laminar Flow-Based Microchemical Systems for Power Generation, Electrochemical Synthesis, and Biological Cell Studies

Similarly in this thesis, multistream laminar flow is used in microfluidic systems for (1) biocatalytic synthesis of fine chemicals by microscale-enabled efficient regeneration of cofactors, as well as for (2) the study of intestinal stem cells on a surface that mimics their in vivo environment. In the first system, the ability to focus reagent streams close to the electrode wall results in a cofactor regeneration efficiency of over 30%. In the second system, microfluidic networks are used to create covalently immobilized surface gradients of extracellular matrix (ECM) proteins, laminin and collagen 1. These microfluidic platforms are capable of eliciting cell responses such as migration, proliferation, and differentiation, and offer the possibility of in vitro studies of a variety cell lines in response to different immobilized and soluble ECM components.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical and Biomolecular Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Choban, Eric Raymond

Contributors dc:contributor

• Kenis, Paul J.A.

• Engineering, Chemical

Language dc:language

eng

Identifier

(MiAaPQ)AAI3160874

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82369