Dietary Omega-3 Fatty Acids, Cell-Mediated Cytotoxicity and Anti-Tumorigenic Activity in Balb/c Mice

Two animal model systems were used to evaluate the effects of an increased consumption of 18:3n-3: cell-mediated cytotoxic (CMC) activity and tumor growth. The most likely mechanism by which dietary 18:3n-3 will alter CMC and tumor growth is through changes in eicosanoid production. One study demonstrated that feeding a diet containing 10% by weight linseed oil (LO), which contains over 50% 18:3n-3, significantly reduced prostaglandin (PG) and leukotriene production by immune cells. That natural and CMC activity after an immunochallenge was generally not altered by LO feeding was shown in a subsequent study. In this same study it was observed that CMC activity in the spleen 6 days after a vaccinia virus challenge was significantly greater in LO-fed compared to control mice fed corn oil (CO).

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Food Science

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Fritsche, Kevin Lee

Contributors dc:contributor

• Johnston, Patricia V.

• Health Sciences, Nutrition
• Health Sciences, Immunology

Language dc:language

eng

Identifier

(UMI)AAI8815343

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/77463