The Effect of Long Term High Protein Induced Calciuria on Calcium Metabolism and Bone Status in Adult Rats

The marked calciuria which occurs during high protein consumption in humans and rats has been implicated as a factor in the etiology of osteoporosis. The source of increased urinary calcium is controversial and has been attributed to either increased absorption, increased bone resorption or both. A 20 week study was conducted to determine long-term effects of various protein sources on calcium metabolism and bone status of 500 g male rats "deep-labelled" with ('45)Ca. Controls were fed diets containing 6% protein as casein and compared to rats fed diets containing 6% casein plus 24% protein as either lactalbumin, beef, casein, soy, egg white or gelatin. Diets supplied all essential nutrients with Mg, P and Ca held constant (0.18, 0.4 and 0.6%, respectively). Protein sources differed in their ability to produce calciuria. Urinary ('45)Ca excretion was greater (P < 0.001) for rats fed lactalbumin, egg white and gelatin diets. The ('40)Ca and ('45)Ca data indicate that the calciuric effect of high protein consumption in adult rats is transient. Long-term consumption of high protein diets did not stimulate increased bone resorption or alter bone mineral composition indicating that bone in not the source of calcium excretion during long term protein-induced calciuria in the rat.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Food Science

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Calvo, Mona Schiess

• Health Sciences, Nutrition

Language dc:language

eng

Identifier

(UMI)AAI8108457

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/77250