Deoxyribozyme-Mediated Synthesis of Branched Nucleic Acids and Application to Modulation of Ribozyme Catalysis

Deoxyribozymes are single-stranded DNA molecules that catalyze a variety of chemical reactions. Catalytic DNAs have not been found in nature but can be identified by in vitro selection from random sequences. In this thesis, deoxyribozymes that ligate two RNA substrates or attach DNA to RNA are identified and characterized. These studies have been useful for understanding fundamental aspects of nucleic acid catalysis and for providing practical reagents.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Zelin, Elena

Contributors dc:contributor

• Silverman, Scott K.

• Chemistry, Biochemistry

Identifier

(UMI)AAI3337983

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/72337