Mechanistic Studies of Lipoxygenases Using Synthetic Substrate Analogues

Lipid peroxidation plays a key role in the biochemistry of living systems. The oxidation of polyunsaturated fatty acids is crucial in pain and inflammation mediation, as well as in cardiovascular, gastrointestinal and reproductive function modulation. However, if excessively stimulated, this process leads to oxidative stress and pathologies such as cancer, atherosclerosis or Alzheimer's disease. Lipoxygenases are one of two enzyme classes that catalyze the first committed steps in the lipid peroxidation pathway.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Jacquot, Cyril

Contributors dc:contributor

• van der Donk, Wilfred A.

• Chemistry, Biochemistry
• Chemistry, Organic

Identifier

(UMI)AAI3337805

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/72246