BoLA Class II Genes: Polymorphism, Disease Association and Linkage Relationships With the Prolactin and Bola-A Genes

Holstein Friesian cattle of known BoLA-A genotype were used to determine whether resistance or susceptibility to persistent lymphocytosis (PL) caused by the bovine leukemia virus is more closely associated with class II genes of the BoLA complex than with BoLA-A. Polymorphisms of BoLA-DQB and -DRB2 genes were identified using restriction fragment length polymorphism (RFLP) analysis. All carriers of DRB2*2A were found to be resistant to PL (P $<$ 0.005), whereas DRB2*1C homozygotes were at higher risk for the development of PL (P $<$ 0.05). There was a closer association of PL with DRB2 than with DQB or BoLA-A.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Van Eijk, Michael Josephus Theresia

Contributors dc:contributor

• Lewin, Harris A.

• Biology, Molecular
• Biology, Genetics
• Health Sciences, Immunology

Identifier

(UMI)AAI9314955

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/72216