Computational Studies of Autocrine Ligand Binding

Autocrine ligand secretion and binding to cell surface receptors regulate cell behavior in a number of important physiological functions. At the same time, some pathological conditions such as the unmitigated growth of tumors can also act through this type of stimulation. Interpretation of experimental studies of autocrine systems is complicated by both the interdependence of system variables and the difficulty in measuring central parameters including secretion rate and receptor number. A mathematical modeling approach offers hope for improved understanding of the kinetic and transport rate processes involved in autocrine cell phenomena.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Forsten, Kimberly Elizabeth

Contributors dc:contributor

• Lauffenburger, Douglas A.

• Chemistry, Biochemistry
• Engineering, Chemical
• Health Sciences, Immunology

Identifier

(UMI)AAI9411623

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/72146