Type III Polyketide Synthases: Discovery, Characterization, and Engineering

The polyketides are a diverse group of natural products with important applications in medicine and industry. Industry, especially the pharmaceutical industry, is under pressure to deliver "greener" chemical syntheses that are less environmentally damaging and incorporate renewable resources. There exists potential to replace current chemical syntheses of natural product or natural product-inspired pharmaceuticals with biological syntheses using enzymes. Polyketide biosynthesis is a particularly attractive target, as polyketide-derived products alone comprise 20% of the top-selling pharmaceuticals.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Pitel, Sheryl Beth Rubin

Contributors dc:contributor

• Zhao, Huimin

• Engineering, Chemical

Identifier

(UMI)AAI3399028

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/72138