Estrogenic and Antiestrogenic Regulation of Cell Proliferation and Tissue Growth

Estrogenic and antiestrogenic responses were investigated in human breast cancer cells and in the rat uterus. I studied the regulation of ornithine decarboxylase (ODC) activity and polyamine concentrations by E2 and antiestrogens (AE) as an aid to understanding the dissimilar effects of E2 and AE on uterine growth. Both E2 and AE stimulated ODC activity. AE were antagonistic to E2 in that pretreatment with either CI628 or U23,469 prevented the second estradiol stimulated peak in ODC activity. Polyamine concentrations on a per cell basis were similarily elevated in E2 or AE treated uteri. The degree to which the uterus is stimulated to grow in response to E2 and/or AE appears to be paralleled closely in the magnitude of its ODC activity and in its total accumulated levels of polyamines per uterus.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Physiology

Grantor

University of Illinois at Urbana-Champaign

Date dc:date

10000-01-01

Author dc:creator

• Kendra, Kari Lynn

• Biology, Animal Physiology

Identifier

(UMI)AAI8721676

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/71450