University of Illinois at Urbana-Champaign
Effect of Nitroxides and Molecular Oxygen on Proton Relaxation Rates in Aqueous Systems and in Lipids
Abstract
dc:descriptionA fundamental investigation of the potential of nitroxides and O$\sb2$ for enhancement of magnetic resonance imaging (MRI) contrast in vivo is presented. The effect of these species on proton relaxation in both aqueous systems and in lipids is studied. The basic experimental approach for this study is the measurement of proton longitudinal relaxation rates (1/T$\sb1$) over a broad range of magnetic field strengths (corresponding to proton Larmor frequencies of 0.01 to 50 MHz), as a function of temperature. The resulting data, nuclear magnetic relaxation dispersion (NMRD) profiles, provide insights into mechanisms of relaxation as well as empirical values that relate to a variety of clinical and experimental NMR instruments. Electron spin resonance data are also utilized to characterize sample containing nitroxides.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Nuclear Engineering
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Bennett, Harold Frank
- Contributors dc:contributor
-
- Swartz, Harold M.
Subjects
dc:subject × 1Identifiers
dc:identifier.*- Identifier
- (UMI)AAI8823081
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/70914