Cellular Movements of Calcium and the Activation Process in Mammalian Heart Muscle

The contractile strength of heart muscle is strongly dependent on the rate of beating, and on the pattern of previous contractions over a period of many seconds. The activator calcium ions, which are responsible for the magnitude of contraction triggered by each action potential, are released from two morphologically and functionally different cellular stores. The characteristics of these stores and the cellular movements of activator calcium were studied by means of simultaneous microelectrode and tension recordings, and measurements of extracellular Ca('++) concentration with Ca('++) -selective electrodes. These electrodes were made from one of the neutral ligands developed by Simon and colleagues (ETH 1001), with the electrode tip diameter 2 to 5 micrometers. The time constant of the electrode-recording system was less than 1 second.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Suh, Chang Kook

• Biology, General

Identifier

(UMI)AAI8310014

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70708