Mechanisms and Intermediates of Iron Bleomycin Catalyzed Oxidations

Based on analogy to other known molecular dioxygen activating metallo-systems, it is presumed that iron bleomycin generates a reactive oxygen intermediate by the reductive cleavage of the dioxygen O-O bond. The molecular details of this activation and the exact chemical nature of the resulting intermediate has remained largely undefined. The ability of ferric bleomycin to use hydroperoxy compounds and mediate the oxidation of small organic substrates in vitro has been utilized in the design of mechanistic studies which probe the chemical mechanisms and reactive intermediates involved in iron bleomycin catalyzed oxidations.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Padbury, Guy

• Health Sciences, Pharmacology
• Chemistry, Biochemistry
• Chemistry, Pharmaceutical

Identifier

(UMI)AAI8908797

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70579