on-Line Liquid Chromatography/fast Atom Bombardment Mass Spectrometry

Directly coupled liquid chromatography/fast atom bombardment mass spectrometry (LC/FABMS) employing a moving belt interface was used to analyze a number of mixtures including the partial hydrolysis products obtained from antiamoebin I, zervamicins IIA and IIB, leucinostatins, trichorzianines, didemnins, and paulomycins A and B, as well as the single components intact antiamoebin I, CC-1014B, and glyceollin. Initial studies using LC/FABMS were performed in conjunction with a jet spray depositor, which yielded weak and unstable signals. Improvements in signal strength and stability were made by the development of the fritted contact depositor, usage of LC microbore technology, and belt conditioning.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

1986

Author dc:creator

• Stroh, Justin G.

• Chemistry, Analytical

Identifier

(UMI)AAI8701628

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70356