Cortical Eeg Following Bilateral Lateral Hypothalamic Damage: Effects of Drugs Acting on Some Components of the Reticular Formation (Hippocampus, Animal-Model, Pharmacology)

Following large bilateral lateral hypothalamic damage (BLH) rats are somnolent (appear behaviorally asleep) and show cortical EEG of high voltage and slow waves (HVS) all the time. The failure to maintain cortical low voltage and fast EEG (LVF) as the normal rat does, may reflect disruption of some neurotransmitter components of the reticular formation known to contribute to cortical LVF-activation. The purpose of this investigation was to find whether drugs which enhance or mimic the action of these reticular neurotransmitter systems (agonists) can establish normal-like cortical LVF. Drugs acting on acetylcholine, dopamine, norepinephrine, and serotonin were found able to advance BLH damaged rats from a condition of early recovery to a condition of later recovery and even to a normal-like cortical EEG. This is the first pharmacological evidence that the damage-induced cortical HVS is due to removal of cortical LVF-activation.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Psychology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Shoham, Shai

• Psychology, Physiological

Identifier

(UMI)AAI8502298

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/69653