Ultramorphological Study of Synaptic Activity and Efficacy Change in the Perifused Rat Hippocampal Slice

This study examined anatomical correlates of synaptic activity produced efficacy change and high levels of continuous synaptic activation which did not produce efficacy change. Long term potentiation in hippocampal CA1 was used as a model of efficacy change. After potentiating stimulation (100Hz for 1 s or 200 Hz for 0.5 s), there were increases in numbers of shaft and nubbin synapses, suggesting an increase in the number of shaft synapses onto inhibitory interneurons and/or an enhancement of synapse formation through a transition of shaft, to nubbin, to full grown spine synapses. Postsynaptic spines also changed to a rounder shape, as indicated by decreases in spine perimeters, contact lengths, and % of 'cup' shaped spines.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Psychology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Chang, Fen-Lei Finland

• Psychology, Physiological

Identifier

(UMI)AAI8309924

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/69621