Hormone Stimulable Adenylyl Cyclase Activity in Ovarian Granulosa Cells of the Domestic Hen (Gallus Domesticus)

The hormone stimulable AC of chicken granulosa cells was characterized and was found to be similar to that of mammalian reproductive tissues under the conditions tested. A principal difference, however, is the stability of the enzyme. Gonadotropin dose response studies suggest that there is an increase in affinity as indicated by the apparent Km, as well as responsiveness of the LH stimulable AC as the follicles mature. In contrast, FSH did not stimulate the AC system appreciably except in F(,3)Gr at very high gonadotropin concentrations. The lack of response argues for the existence of an FSH-AC system which develops earlier during follicular maturation and is waning by the time a follicle enters the hierarchy. This phenomenon is analogous to that found in mammals.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Physiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Calvo, Francisco Omar

• Biology, Animal Physiology

Language dc:language

eng

Identifier

(UMI)AAI8108456

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/68305