Chromatin Structure, Dna Methylation and Vitellogenin Gene Expression

The methylation patterns and the chromatin conformation of the Xenopus vitellogenin genes were examined to determine their relationship to the transcriptional state of the genes. The role of these two potential regulatory mechanisms was of particular interest because the estrogen induction of vitellogenin mRNA does not simply involve modulation of the rate at which a set of genes which are transcriptionally active in the absence of hormone is transcribed. Instead it involves the switching on of a set of transcriptionally inactive genes in a stable non-dividing cell type. The fact that the induction of vitellogenin is such an immense response made the study of the regulatory mechanisms responsible for this hormonal induction even more interesting.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Bruce, Kim R. Folger

• Chemistry, Biochemistry

Language dc:language

eng

Identifier

(UMI)AAI8203411

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/67415