High-speed polarization-sensitive optical coherence tomography: toward intraoperative cancer imaging

Successful treatment of most breast cancers requires surgical removal of the tumor. The current standard-of-care does not provide any tools for real-time assessment of the tumor cavity. Optical coherence tomography (OCT) has previously been developed for real-time intraoperative use in hopes of aiding tumor margin assessment. While there has been much success, it remains difficult to distinguish between normal stroma tissue and breast cancer. Polarization-sensitive optical coherence tomography (PS-OCT) is an extension of OCT that measures both the intensity and polarization of light returning from the tissue. PS-OCT is sensitive to changes in collagen structure and may provide additional contrast between normal and diseased tissue. This thesis reports the development of a real-time PS-OCT system using a high-speed swept-source laser and parallel processing on a graphics processing unit (GPU). Results of a preliminary imaging study are also reported, demonstrating that PS-OCT provides enhanced contrast between previously indistinguishable fibrous stroma and invasive ductal carcinoma (IDC).

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Electrical & Computer Engr

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• South, Fredrick A.

Contributors dc:contributor

• Boppart, Stephen A.

• biomedical imaging
• optical coherence tomography
• breast cancer
• polarization

Statement dc:rights

• Copyright 2013 Fredrick South

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/46580

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/46580