Spontaneous lipid transfers between low density lipoproteins and reconstituted high density lipoproteins

Spontaneous lipid transfers are important components in the metabolism of low density lipoprotein (LDL) and high density lipoprotein (HDL). Cholesterol spontaneously transfers from LDL to HDL; phospholipid transfer proceeds in the reverse direction. Reconstituted HDL (rHDL) particles were employed in this study. Cholesterol transfer from LDL to rHDL depended on the ratio of the two particles and their concentrations. When rHDL exceeded LDL, transfer became independent of rHDL concentration. These experiments are consistent with the aqueous diffusion mechanism of cholesterol transfer.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Bottum, Kathleen Mary

Contributors dc:contributor

• Jonas, Ana

• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1995 Bottum, Kathleen Mary

Language dc:language

eng

Identifier

AAI9543537
(UMI)AAI9543537

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/23318