The cloning and molecular regulation of rat 3-hydroxy-3-methylglutaryl coenzyme A reductase

We have cloned and sequenced the cDNA for rat HMG-CoA reductase the key regulatory enzyme in the mevalonate pathway. The amino acid sequence of rat HMG-CoA reductase is highly homologous to hamster and human reductases. Noncoding regions of the reductase mRNAs are also highly conserved. Rat HMG-CoA reductase mRNA is initiated at a single cluster of start sites about 105 bases from the start of translation. Six conserved serines in the linker domain has been identified as possible sites for protein phosphorylation.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Williams, David Lee

Contributors dc:contributor

• Shapiro, David J.

• Biology, Molecular
• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1990 Williams, David Lee

Language dc:language

eng

Identifier

AAI9026351
(UMI)AAI9026351

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/23293