Biosynthetic and structural studies of neomycin and berninamycin

($\sp{13}$C$\sb6$) Glucose (3) was supplemented to seven-days old resting cells of neomycin B-proucing S.fradiae. The $\sp{13}$C NMR spectra of the enriched neomycin B (2) showed complex coupling patterns which suggested that 3 is not incorporated as an intact C$\sb6$ unit into the carbon skeleton of 2. These complex splitting patterns of 2 can be explained when 3 is first shunted through the pentose phosphate pathway to form primary metabolites of different carbon length. Some of these metabolites are then reconstituted back to six-carbon unit for the biosynthesis of 2.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Lau, Raymond Chung Man

Contributors dc:contributor

• Rinehart, Kenneth L., Jr.

• Chemistry, Organic
• Chemistry, Pharmaceutical

Statement dc:rights

• Copyright 1990 Lau, Raymond Chung Man

Language dc:language

eng

Identifier

AAI9114306
(UMI)AAI9114306

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/23172