Modeling dual-limitation kinetics incorporating intracellular cofactor responses

Intracellular cofactors--such as NADH, NAD, ATP, ADP, and P$\sb{\rm i}$--are important co-substrates that can affect the rate of the cell's catabolic and respiratory reactions. Pure-culture experiments with Pseudomonas putida P$\sb{\rm p}$F1 performed in a special chemostat apparatus, using acetate as electron donor and O$\sb2$ as electron acceptor, revealed that the cofactor concentrations vary highly systematically with changes in availability of the external electron donor and acceptor. In general, the NAD/NADH ratio increased as the DO concentration rose or the acetate concentration fell, while the ATP/ADP$\cdot$P$\sb{\rm i}$ value increased as the electron-donor utilization rate decreased.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Environmental Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Bae, Wookeun

Contributors dc:contributor

• Rittmann, Bruce E.

• Engineering, Civil
• Engineering, Electronics and Electrical

Statement dc:rights

• Copyright 1992 Bae, Wookeun

Language dc:language

eng

Identifier

AAI9236394
(UMI)AAI9236394

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/22072