Neurobehavioral and neurochemical effects of ortho-substituted polychlorinated biphenyl congeners in perinatally exposed rats

Polychlorinated biphenyls (PCBs) are persistent contaminants in the environment. PCBs are lipophilic and from the environment bioaccumulate in living organisms. People are exposed to PCBs through the food chain. PCB exposure during development of the central nervous system (CNS) results in behavioral dysfunction and impaired learning and memory. There are two major classes of PCBs, coplanar and ortho-substituted (OS) congeners. Most of the PCBs in environmental mixtures are the OS congeners. In vivo and in vitro studies suggest that the neurotoxic effects of PCBs might be due to exposure of the CNS to OS congeners, but there is little information on the neurobehavioral effects of these congeners.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Biosciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Moshtaghian, Jamal

Contributors dc:contributor

• Hansen, Larry G.

• Biology, Neuroscience
• Health Sciences, Toxicology
• Environmental Sciences

Statement dc:rights

• Copyright 1996 Moshtaghian, Jamal

Language dc:language

eng

Identifier

9780591089189
AAI9702616
(UMI)AAI9702616

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21999