Characterization of a single-chain anti-T cell receptor antibody and a single-chain T cell receptor

The T cell receptor (TCR) is a cell surface protein that specifically binds to a foreign antigen on the surface of another cell. The TCR is made up of two disulfide-linked chains (called α and β) each containing a variable and a constant domain. The tertiary structure and binding properties (e.g. affinity and kinetics) of the TCR have not been solved. Additionally, the T cell has been implicated in many autoimmune diseases and some reports show that antibodies to the TCR may possibly control these diseases.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Schodin, Beth Arlene

Contributors dc:contributor

• Kranz, David M.

• Chemistry, Biochemistry
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1995 Schodin, Beth Arlene

Language dc:language

eng

Identifier

AAI9543717
(UMI)AAI9543717

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21781