Toxicity of microcystin-LR in hepatocytes and non-hepatocytes in vitro

Microystin-LR (MCLR), a cyanobacterial heptapeptide is an inhibitor of protein phosphatases 1 and 2A (PPs), a potential tumor promoter in rat liver, and selectively toxic to the liver in vivo and isolated hepatocytes in vitro. Inhibition of PPs has been linked to excessive phosphorylation and collapse of intermediate filaments (IFs) in hepatocytes. MCLR was used as a probe to understand the mechanism of action of this toxin in hepatocytes and non-hepatocytes.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Pathobiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Khan, Safdar Ali

Contributors dc:contributor

• Beasley, Val Richard

• Agriculture, Animal Pathology
• Health Sciences, Pathology
• Biology, Veterinary Science

Statement dc:rights

• Copyright 1994 Khan, Safdar Ali

Language dc:language

eng

Identifier

AAI9503231
(UMI)AAI9503231

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21679