Localization of the prosthetic group ligands of cytochrome o terminal oxidase complex of Escherichia coli

The cytochrome o ubiquinol oxidase is one of two terminal oxidases present in the aerobic respiratory chain of E. coli. The cytochrome o complex has been purified and found to contain two protoheme IXs and one copper atom. Subsequently the gene encoding the cyo operon has been cloned. The research presented in this thesis focuses on the continued structural analysis of the cytochrome o oxidase complex including the following areas of interest: (i) the DNA sequence of the cyo operon, (ii) subunit analysis, (iii) localization of the prosthetic groups of this complex to specific subunits and (iv) determination of the histidines responsible for ligating the prosthetic groups of this complex.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Lemieux, Laura Jean

Contributors dc:contributor

• Gennis, Robert B.

• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1991 Lemieux, Laura Jean

Language dc:language

eng

Identifier

AAI9136656
(UMI)AAI9136656

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21571