Intermediates of coenzyme A biosynthesis in colon tissue: Normal vs inflammatory bowel disease

A specific deficiency syndrome for pantothenic acid in man has not been identified. Gastrointestinal ulcers have been repeatedly produced by pantothenic acid deficiencies in many species of animals, particularly mice, rats and swine. Of particular interest is the fact that pantothenic acid deficiency in swine produces a syndrome virtually indistinguishable from chronic ulcerative colitis in humans. The inflammatory lesions in swine were associated with lowered levels of coenzyme A, the biologically active form of pantothenic acid. Colonic mucosal tissue removed from humans with chronic ulcerative colitis or Crohn's colitis has been shown to have significantly less coenzyme A activity than tissue removed from patients with noninflammatory conditions.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Human and Community Development

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Gloeckner, Janet Wilson

Contributors dc:contributor

• Layman, Donald K.

• Health Sciences, Medicine and Surgery
• Health Sciences, Nutrition

Statement dc:rights

• Copyright 1992 Gloeckner, Janet Wilson

Language dc:language

eng

Identifier

AAI9236467
(UMI)AAI9236467

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21167